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Dira Sengwe meaning “take action” is a South African-based non-Governmental Organisation (NGO) established in 2002 by the members of the local organizing committee of the ground-breaking XIIIth International Aids Conference, Durban 2000. The organization emerged at a critical period in the history of the struggle for the recognition of HIV and AIDS as a disease, overwhelmingly in poor countries, especially on the African continent.

This achieved and accounted for the subsequent success of Dira Sengwe. Dira Sengwe is the custodian of the National Aids Conference in South Africa and the secretariat duties of the organization are performed by the Foundation for Professional Development (FPD). Dira Sengwe is rooted in addressing the quintessential disequilibrium of the HIV and AIDS pandemic in the world.

The events around the landmark XIIIth International Aids Conference, Durban 2000, led to profound changes in the struggle against the high costs of antiretroviral drugs, discordance between the state and the scientific and civil society, and the mobilization of the global scientific community to support the scientific foundations of the cause and management of HIV andAIDS[The Durban Declaration-a unique document].